The Pasadena Chair for the Pediatrician-In-Chief, Senior Vice President of Academic Affairs

$3 Million Dollars  ·  Dr. Robert E. Shaddy

The Pasadena Guild Endowed Chair for the Pediatrician-in-Chief will help shape the future of pediatric care in our community by supporting visionary leadership and the Hospital’s goal of expanding existing programs and providing multidisciplinary care to more patients in Southern California and beyond.

The inaugural chair holder is Robert E. Shaddy, MD, CHLA’s current Pediatrician-in-Chief, who is an internationally renowned cardiologist with more than 25 years of experience caring for children. Dr. Shaddy oversees faculty appointments as well as educational and research activities, including clinical trials and studies performed at The Saban Research Institute of CHLA, where scientists work to improve treatment options and outcomes for a wide range of pediatric diseases. Dr. Shaddy’s own research has focused on the use of echocardiography and other imaging techniques, transplant coronary artery disease, the effectiveness of pharmaceutical drugs in treating heart failure and the use of ventricular assist devices in children. In addition, Dr. Shaddy is currently conducting the only worldwide clinical trial designed to create lifesaving protocols for children with pediatric heart failure and pediatric heart transplantation needs. The Guild is pleased to endow this significant chair supporting the primary leadership of Children’s Hospital as well as groundbreaking heart research. 

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Pasadena Guild Endowed Chair in Developmental Biology and Regenerative Medicine

$3 Million Dollars  ·  Dr. David Warburton

An internationally recognized expert on child health and lung development, Dr. Warburton established the Developmental Biology and Regenerative Medicine Program in 1966, with a focus on discovering the basic mechanisms of human organ development, repair and regeneration to enable innovative treatments for improved clinical outcomes.  Since that time, under his careful, nurturing and visionary leadership, DBRM has grown to over 25 collaborating faculty with numerous publications in high impact journals, diverse funding profiles and national and international reputations. Dr. Warburton’s major contributions range from clinical studies establishing management practices of extreme prematurity, to infants of diabetics, to basic mechanisms of organ morphogenesis, repair and regeneration.  He is a seminal figure in neonatal-perinatal medicine, developmental biology, stem cell biology and regenerative medicine. His most highly cited work established and leads the field of molecular embryology of the lung, showing how growth factors and matrix molecules direction formation and repair of the gas exchange surface.

The Pasadena Guild’s endowed chair has ensured Dr. Warburton’s sustainability and foster his ability to attract outstanding trainees, further the innovative research currently under study, and mentor early and mid-career faculty — all of which aggressively impact CHLA and The Saban Research Institute globally across the domains of education, training, mentoring, research and clinical care. 

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Pasadena Guild Endowment for Program Enhancement and Faculty Retention in Developmental Biology

$3 Million Dollars  ·  Dr. David Warburton

The Pasadena Guild has provided critical support for CHLA’s priority program in Developmental Biology.  The program focuses on fundamental discoveries in the mechanisms involved in the development of organs like the lung, pancreas, gut, heart and palate, which are the source of many diseases that affect babies and young children, including respiratory failure due to prematurity, atresia of the bowel, short bowel syndrome, cardiac malformation, and cleft lip and palate.  This important research is conducted by a group of scientists and physicians working together toward the discovery of innovative approaches to tissue repair and tissue regeneration. The Pasadena Guild’s Endowment for Program Enhancement and Faculty Retention in Developmental Biology has ensured that CHLA is able to attract, support and retain top researchers, faculty members and scientists to the program.

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Pasadena Guild Endowment for Developmental Biology & Regenerative Medicine

$5.5 Million Dollars  ·  Dr. David Warburton

The Developmental Biology and Regenerative Medicine Research Program at The Saban Research Institute continues to make strides in its quest to find new approaches for repairing vital organs such as the lung, heart, kidney, intestines, liver, pancreas and skin. With the support of several Pasadena Guild endowments established for the program, a team of 20 faculty members and up to 100 staff delve into the basic mechanisms of human organ development, repair and regeneration, searching for improved ways to treat a wide spectrum of pediatric illnesses.  

At its core, the program strives to understand the fundamental building blocks of human and animal cell development and the effect of diseases. This knowledge can then be used to unravel the molecular and genetic basis of normal and abnormal organ repair, harness the power of cell-based organ regeneration and discover methods of tissue reconstruction.

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Pasadena Guild Newborn and Infant Critical Care Suite

$1 Million Dollars  · 

The Pasadena Guild’s million dollar donation provided a state-of-the-art suite for newborns and infants requiring heightened levels of critical medical care. Located on the third floor in the NICCU in the Anderson Pavilion of CHLA, the Pasadena Guild Suite provides cutting edge technology for specialized treatment across the full range of neonatal diseases. The suite allows children direct access to a wide range of  pediatric medical and surgical subspecialists and ancillary services, and also provides comfortable in-suite provisions for parents to stay overnight with their child.

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Pasadena Guild Endowment for Bone and Soft Tissue Tumor Research

$2 Million Dollars  ·  Dr. Marcio Malogolowkin

Led by Leo Mascarenhas, MD, MS, the Bone and Soft Tissue Tumors Program at Children’s Hospital Los Angeles treats children and adolescents with malignant tumors such as osteosarcoma, Ewing sarcoma and rhabdomyosarcoma, as well as benign bone and soft tissue tumors and vascular anomalies. Oncologists partner with orthopedic surgeons from the Children’s Orthopedic Center at CHLA to care for more children with bone and soft tissue tumors than any other pediatric hospital west of the Mississippi. A critical component of the program is the Clinical Trials Program, overseen by Dr. Mascarenhas. He and his team of researchers work closely with other pediatric cancer centers around the world to test new agents and combinations of agents through clinical trials (phase I, II and III) to develop therapies that hold the promise of improving outcomes and increasing survival rates for patients with bone and soft tissue tumors. In addition, the team is conducting research studies on the effects of minimally invasive treatment of benign bone tumors, reconstruction following tumor resection, and management of long-term issues related to cancer treatment.  The Pasadena Guild Bone and Soft Tissue Tumors Endowment provides critical support for these important endeavors.

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Pasadena Guild Endowment for Adolescent Medicine

$2.5 Million Dollars  ·  Dr. Richard Mackenzie

The Pasadena Guild Endowment for Adolescent Medicine has provided critical support to CHLA’s nationally recognized Division of Adolescent and Young Adult Medicine.  Adolescence can be one of the most pivotal periods of a child’s life. It marks a transition that can set the stage for young boys and girls to thrive as adults. The Division of Adolescent and Young Adult Medicine at CHLA is committed to promoting healthy futures by providing holistic care that attends to the physical, emotional and social needs of young people ages 12 to 25. A team of Board-certified adolescent medicine physicians, along with psychologists, social workers and health educators, focuses on health promotion, treatment and prevention using a model of positive youth development.

The Pasadena Guild Endowment for Adolescent Medicine plays an essential role in the Division’s ability to treat more than 7,500 youth every year. The fund’s income helps support key operating and programmatic priorities—spanning from clinical care services to advocacy and grant writing opportunities.

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Pasadena Guild Endowment for Pediatric Surgical Research

$1.5 Million  ·  Dr. Kathryn Anderson

Necrotizing enterocolitis (NEC), a severe intestinal inflammation affecting predominantly very low weight infants, is one of the leading causes of long-term morbidity and mortality and a major obstacle in improving survival rates at neonatal intensive care units.  Conquering this disease remains the ultimate goal of the Department of Surgery’s leading investigations. The Pasadena Guild’s endowment has allowed CHLA’s surgical research specialists, led by Dr. Anatoly Grishin, PhD, to gain a deeper understanding of how and why NEC develops.  

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Pasadena Guild Endowment for Pediatric Eye Cancer Research

$1.7 Million Dollars  ·  Dr. Linn Murphree and Dr. Teddy Fung

The Guild’s Endowment for Pediatric Eye Cancer Research has fueled the efforts for 18 clinical trials that focus on groundbreaking therapies for children affected by retinoblastoma (RB) and other cancers as a result of mutations in the RB Gene.  The Vision Center at Children’s Hospital Los Angeles is an international referral center for children with complex eye diseases, and is the only program of its kind in the United States with expertise in virtually every pediatric ophthalmologic subspecialty. Working in six separate areas of expertise, its physician-scientists are helping children to see every day through the latest medical and surgical treatments, as well as leading-edge research that will change the lives of families across the globe.

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